We are recruiting an experienced researcher for our work on biomarkers. The title of the project is “Cerebrospinal fluid – and blood biomarkers in dementia with Lewy bodies and related disorders”. The goal is to identify biomarkers and biomarker combinations from cerebrospinal fluid and plasma and serum, both established markers of Alzheimer’s disease and new markers, to aid in diagnosis and prognosis. patients with DLB and Parkinson’s disease and other neurodegenerative disorders.
Methods and techniques
The work involves investigating the relationship between different markers and combinations of markers and patient outcomes at King’s College Hospital and South London and Maudsley NHS Foundation Trust, and collaborating groups. To maximize the chances of detecting markers with more subtle effects, we will include patient data from partner sites. We are running the UK DLB Accelerated Network (ENLIST) study funded by ARUK (PI Aarsland) with five different UK centres, which collect blood and CSF. Additionally, we collaborate with and will receive material from the Karolinska Institute in Sweden, Stavanger and Oslo in Norway, and the European DLB Consortium (E-DLB), the largest DLB cohort in the world led by Professor Aarsland . The project will work closely with our collaborators in the Neuroscience Laboratory at Sahlgrenska University, Gothenburg, Sweden. (Dr Nicholas Ashton).
Dissemination and implementation
The results will be of international significance and will appeal to high-level conferences and journals. If the project identifies new markers or combinations of markers that better predict poor outcomes in DLB, it is envisioned that the new approaches will be rapidly integrated into existing research studies such as E-DLB and into clinical practice of routine in the NHS and across Europe. The ability to identify patients at risk of poorer outcomes would have immediate positive effects in planning future care and targeting patients for therapeutic intervention to mitigate poor outcomes. Our local group of expert Parkinson’s patients and the Patient and Public Involvement (PPI) dementia specialist group will be involved in the project at all stages, helping to plan how the study will be designed and implemented. work. The involvement of patients with PD and caregivers or former caregivers of people with dementia ensures that the study results are relevant to people living with these conditions and that it is conducted in a way that participants find it rewarding and engaging. The supervising team is highly experienced in this type of research with expertise in imaging, CSF and blood markers and clinical manifestations of DLB and PDD. The project offers an unprecedented opportunity for a clinical student to develop cutting-edge experience in the development of dementia biomarkers with the support of an internationally renowned supervisory team in this field.
This position will be offered on a fixed term contract of 6 months initially but there is a possibility of extension
This is a full-time position – 100% full-time equivalent
• Initiate, direct, organize and conduct advanced laboratory research to identify novel biomarkers and biomarker combinations for DLB and related disorders
• Develop research protocols for the different experimental components. Perform a systematic review to establish hypotheses. To prepare data applications. Be the primary point of contact for Research Ethics Board applications.
• Perform quantitative data analyzes using specialized software.
• Be responsible for the administration of research tasks, including data collection and analysis, and for ensuring ethical and good clinical practice in all undertakings.
• Prepare presentations, reports and publications as required, and review the scope and impact of these in relation to extending the scope of research.
• Actively contribute to the educational program of the Institute
The above list of responsibilities may not be exhaustive and the post holder will be required to undertake the duties and responsibilities reasonably expected within the scope and classification of the post.
Skills, knowledge and experience
- PhD in Neuroscience
- Relevant undergraduate degree (equivalent in biological sciences)
- Experience working with cutting-edge technology for biomarker measurements
- Experience with biochemical techniques (Western Blot, immunoprecipitation, immunoassays – ELISA)
- Experience in statistical analysis (univariate and multivariate) of large scale data
- Experience working with multicenter projects, networking and coordinating and processing samples from multiple centers, including overseas
- Proven track record in planning, conducting, analyzing, reporting and publishing successful research in top international scientific journals
- Excellent written and verbal communication
- Evidence of good teamwork, especially the ability to interact positively with project colleagues.
- Excellent organizational skills and time management skills
1. Research publication(s) in a peer-reviewed journal
2. Relevant experience in high-level independent research
3. Undergraduate/postgraduate teaching and supervision experience
This position is subject to occupational health clearance.