This position will be based in the Inflammation Biology Group led by Professor Toby Lawrence at the Center for Biology of Inflammation and Cancer Immunology (CIBCI) and in close collaboration with the Cancer Systems Immunology Group led by Dr. Shahram Kordasti, both based at the Guy Hospital campus. . The CIBCI aims to leverage expertise in the biology of inflammation to expand fundamental and applied knowledge of tumor immunobiology. In this context, the incumbent will develop new analytical workflows and pipelines for the acquisition of multidimensional datasets, including single-cell RNA sequencing, imaging mass cytometry and spatial transcriptomics, from patient samples and experimental models, with the ultimate goal of deconstructing the tumor immune microenvironment and its impact on cancer using functional genomics. The post holder will also be involved in the training and supervision of PhD students and junior research associates involved in related projects.
This position will be offered on a fixed-term contract until 31/03/23 with the possibility of extension for another 2 years
This is a full time position
• Work on immunological and molecular profiling of patient and tissue samples from animal and patient models.
• Develop mechanistic knowledge derived from these profiling activities in collaboration with clinical and basic scientists
• Use a variety of technologies to study the functional immunological status of cancers and the influence of their microenvironments
• Create, implement and use analytical and bioinformatics tools to analyze and interpret multidimensional data.
• Establish the pipelines for the collection and analysis of patient samples and enable the development of experimental protocols.
• Support the writing of grants and manuscripts to maintain ongoing research in this area.
• Promote research initiatives and original contributions to the Centre’s, Department’s, School’s and Faculty’s research programs.
• Design and implement laboratory information management systems (both electronic and manual) and archiving of analytical material.
• Develop and improve their own scientific knowledge and awareness of developments in the field of molecular and cellular immunology by participating in relevant meetings and conferences, both nationally and internationally.
• Develop new original research projects based on a thorough assessment of the published literature and advice from the research group leader (Prof Lawrence).
• Prepare grant applications, project rationales, business cases and project reports.
• Prepare manuscripts for publication in peer-reviewed academic journals.
• Present research work at national and international meetings promoting the department while establishing useful contacts in the field and engaging other scientists in the development of strategies.
• Regularly supervise and train junior scientific and technical staff, students and visiting staff members working in the laboratory.
• Facilitate the professional development of junior staff through a mentorship approach.
The above list of responsibilities may not be exhaustive and the post holder will be required to undertake the duties and responsibilities reasonably expected within the scope and classification of the position.
Knowledge of skills and experience
• Doctoral degree awarded in a relevant discipline, or equivalent
• Knowledge of relevant platforms and techniques
• Knowledge of immunology, any prior laboratory experience is advantageous.
• Knowledge/skills in the use of platforms for monitoring the immunological and/or microenvironmental status of patients
• Previous peer-reviewed publication(s) involving the use of platforms monitoring the immunological and/or microenvironmental status of the patient
• Advanced skills with Microsoft packages such as Word and Excel
• Knowledge of computational biology
• Computational skills required for statistical analysis of experimental data, including knowledge of a specialized statistical package (i.e. SPSS or similar)
• Ability to analyze data with publicly available and commercial software solutions (eg R/Bioconductor, UMAP, viSNE, SPADE, FlowJo, CytoBank suite)
• Develop new tools using statistical, mathematical and machine learning approaches for the analysis of high-dimensional data.
• Interest in the field of translational cancer research
• Leadership – able to motivate others, encourage teamwork, delegate and get the best out of people
• Analysis and Understanding – able to analyze and evaluate evidence; for example in planning, problem solving and decision making
• Time management – able to plan and use time economically and efficiently
* Please note that this is a PhD level position, however applicants who have submitted their thesis and are awaiting their PhD will be considered. In these circumstances, the appointment will be in 5th year, spine 30 with the title of research assistant. Upon confirmation of the PhD award, the job title will change to Research Associate and the salary will increase to Grade 6.
This position is subject to Disclosure and Barring Service and Occupational Health clearance.